Issue 7, 2001

The efficient, enantioselective synthesis of quinoxaline, pyrazine and 1,2,4-triazine substituted α-amino acids from vicinal tricarbonyls

Abstract

The reaction of diamines and amidrazones with α-amino acid vicinal tricarbonyls has been shown to be a versatile route towards novel heterocyclic α-amino acids. This route is also applicable to parallel synthesis and has allowed the formation of a range of heterocyclic amino acid systems.

Graphical abstract: The efficient, enantioselective synthesis of quinoxaline, pyrazine and 1,2,4-triazine substituted α-amino acids from vicinal tricarbonyls

Article information

Article type
Paper
Submitted
19 Dec 2000
Accepted
16 Feb 2001
First published
19 Mar 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 668-679

The efficient, enantioselective synthesis of quinoxaline, pyrazine and 1,2,4-triazine substituted α-amino acids from vicinal tricarbonyls

R. M. Adlington, J. E. Baldwin, D. Catterick and G. J. Pritchard, J. Chem. Soc., Perkin Trans. 1, 2001, 668 DOI: 10.1039/B010134F

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