Issue 5, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthesis of novel 5-amino-6-ethoxy-2-alkylpyrimidine-4-carbonitriles

Amal Al-Azmi,a   Brian L. Booth,*a   Robin G. Pritcharda  and  Fernanda J. R. P. Proençab  

* Corresponding authors

a Department of Chemistry, University of Manchester Institute of Science and Technology, Manchester, UK

b Department of Chemistry, University of Minho, Braga, Portugal

Abstract

Formation of highly functionalised 5-amino-6-ethoxy-2-alkylpyrimidine-4-carbonitriles has been shown to occur by simply refluxing in ethanol the N-(2-ammonio-1,2-dicyanovinyl)alkylamide chloride or, under acid catalysis conditions, N-(2-amino-1,2-dicyanovinyl)acetamide derivatives, which are readily prepared from diaminomaleodinitrile.

Graphical abstract: Synthesis of novel 5-amino-6-ethoxy-2-alkylpyrimidine-4-carbonitriles

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Article information

DOI
https://doi.org/10.1039/B009804N
Article type
Communication
Submitted
06 Dec 2000
Accepted
24 Jan 2001
First published
16 Feb 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 485-486

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Synthesis of novel 5-amino-6-ethoxy-2-alkylpyrimidine-4-carbonitriles

A. Al-Azmi, B. L. Booth, R. G. Pritchard and F. J. R. P. Proença, J. Chem. Soc., Perkin Trans. 1, 2001, 485 DOI: 10.1039/B009804N

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