Heterocycles of biological importance. Part 5. The formation of novel biologically active pyrimido[1,2-a]benzimidazoles from allenic nitriles and aminobenzimidazoles

Peter Forche Asobo; Helene Wahe; Joseph Tanyi Mbafor; Augustin Ephraim Nkengfack; Zacharias Tanee Fomum; Emmanuel Fondjo Sopbue; Dietrich Döpp

doi:10.1039/B005511P

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Heterocycles of biological importance. Part 5.¹ The formation of novel biologically active pyrimido[1,2-a]benzimidazoles from allenic nitriles and aminobenzimidazoles

Peter Forche Asobo,^a Helene Wahe,^a Joseph Tanyi Mbafor,^a Augustin Ephraim Nkengfack,^a Zacharias Tanee Fomum,*^a Emmanuel Fondjo Sopbue^b and Dietrich Döpp^c

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* Corresponding authors

^a Department of Organic Chemistry, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon

^b Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon

^c FB 6, Organische Chemie, Gerhard-Mercator-Universität-Duisburg, Duisburg, Germany

Abstract

The reaction of allenic nitriles with 2-aminobenzimidazoles gives 2-aminopyrimido[1,2-a]benzimidazoles 5 in very good yields. The pharmacological screening of compound 5a, 5d and 5i shows that they possess slight antibiotic and antiarrythmic properties.

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Article information

DOI: https://doi.org/10.1039/B005511P
Article type: Paper
Submitted: 10 Jul 2000
Accepted: 07 Dec 2000
First published: 01 Feb 2001

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J. Chem. Soc., Perkin Trans. 1, 2001, 457-461

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Heterocycles of biological importance. Part 5. The formation of novel biologically active pyrimido[1,2-a]benzimidazoles from allenic nitriles and aminobenzimidazoles

P. Forche Asobo, H. Wahe, J. T. Mbafor, A. E. Nkengfack, Z. T. Fomum, E. F. Sopbue and D. Döpp, J. Chem. Soc., Perkin Trans. 1, 2001, 457 DOI: 10.1039/B005511P

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Journal of the Chemical Society, Perkin Transactions 1