Fluorine-containing α-alkynyl amino esters and access to a new family of 3,4-dehydroproline analogues†
Abstract
New α-alkynyl, α-CF3 amino esters have been prepared from electrophilic imines and used to produce 3-alkenyl-3,4-dehydroproline
derivatives, ia enyne metathesis with the precatalyst [Ru
C
C
CPh2(Cl)(PCy3)(arene)]O3SCF3.
These new conjugated fluorine-containing dienes
are active substrates for the Diels–Alder reaction and lead
to a new class of bicyclic
amino esters.