Issue 1, 2001

Prins reaction under manganese dioxide control: the synthesis of 6-oxa-2-azabicyclo[3.2.1]octan-4-ones from tetrahydropyridines and formaldehyde

Abstract

The course of the acid-catalysed Prins reaction of tetrahydropyridines 1 with formaldehyde, leading to derivatives of piperidino-dioxane 4 and 3-oxa-7-azabicyclononanes 5 and 6, is dramatically changed in the presence of manganese dioxide to give new products, 6-oxa-2-azabicyclo[3.2.1]octan-4-ones 7 and 8.

Article information

Article type
Paper

Mendeleev Commun., 2001,11, 27-29

Prins reaction under manganese dioxide control: the synthesis of 6-oxa-2-azabicyclo[3.2.1]octan-4-ones from tetrahydropyridines and formaldehyde

A. T. Soldatenkov, K. B. Polyanskii, A. W. Temesgen, S. A. Soldatova, N. D. Sergeeva, N. M. Kolyadina and N. N. Lobanov, Mendeleev Commun., 2001, 11, 27 DOI: 10.1070/MC2001v011n01ABEH001386

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