Selective synthesis of 5-methyl-2-phenylpyridine from carbonyl compounds and ammonia over zeolite catalystsIICT Communication No. 4735.

Abstract

The vapor-phase cyclization of acetophenone, propionaldehyde, formaldehyde and ammonia was carried out over HZSM-5, Hβ and HY zeolites at 400 °C and 0.5 h⁻¹ weight hour space velocity to synthesize 5-methyl-2-phenylpyridine. The cyclization activity follows the order: HY > Hβ > HZSM-5. The influence of catalyst modification with a metal ion, temperature, feed molar ratio, weight hour space velocity, and activity with time on stream parameters were studied. The maximum yield of 5-methyl-2-phenylpyridine was obtained over 3 wt% CoHY zeolite at 400 °C.