Issue 21, 2001
From the journal:

Chemical Communications

Structural transformations in zopiclone

Norman Shankland,*a   William I. F. David,b   Kenneth Shankland,b   Alan R. Kennedy,c   Christopher S. Framptond  and  Alastair J. Florencea  

* Corresponding authors

a Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, UK
E-mail: n.shankland@strath.ac.uk;
Fax: +44 141 552 6443;
Tel: +44 141 548 2969

b ISIS Facility, Rutherford Appleton Laboratory, Chilton, Oxon., Didcot, UK

c Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK

d Roche Discovery Welwyn, Herts., Welwyn Garden City, UK

Abstract

A monoclinic centrosymmetric form of zopiclone dihydrate undergoes a sequential, two-step transformation in the solid-state upon heating which results in separation of the enantiomers into a racemic conglomerate or racemic twins.

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Article information

DOI
https://doi.org/10.1039/B107075D
Article type
Communication
Submitted
08 Aug 2001
Accepted
04 Sep 2001
First published
11 Oct 2001

Chem. Commun., 2001, 2204-2205

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Structural transformations in zopiclone

N. Shankland, W. I. F. David, K. Shankland, A. R. Kennedy, C. S. Frampton and A. J. Florence, Chem. Commun., 2001, 2204 DOI: 10.1039/B107075D

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