Issue 20, 2001

A new practical ketone synthesis directly from carboxylic acids: first application of coupling reagents in palladium catalysis

Abstract

A new palladium-catalyzed cross-coupling reaction between arylboronic acids and carboxylic acids, activated in situ for the oxidative addition to a tricyclohexylphosphine palladium(0) catalyst by treatment with di(N-succinimidyl) carbonate (DSC) is disclosed, which allows the high-yielding synthesis of various functionalized arylketones under mild conditions.

Article information

Article type
Communication
Submitted
26 Jul 2001
Accepted
05 Sep 2001
First published
01 Oct 2001

Chem. Commun., 2001, 2084-2085

A new practical ketone synthesis directly from carboxylic acids: first application of coupling reagents in palladium catalysis

L. J. Gooßen and K. Ghosh, Chem. Commun., 2001, 2084 DOI: 10.1039/B106779F

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