Issue 24, 2001
From the journal:

Chemical Communications

Facile enantioselective synthesis of a key homoallylic alcohol building block for polyketide synthesis: TiF4–BINOL catalyzed allylsilylation with allyl trimethylsilane

Jeffrey W. Bode,a   Donald R. Gauthier Jr.a  and  Erick M. Carreira*a  

* Corresponding authors

a Laboratorium für Organische Chemie, ETH-Zentrum, Universitätstrasse 16, Zürich, Switzerland.
E-mail: carreira@org.chem.ethz.ch

Abstract

The titanium fluoride–BINOL catalyzed asymmetric allylsilylation of α,α-disubstituted aldehydes provides facile access to highly functionalized, chiral building blocks, which following simple recrystallization affords a key versatile starting material for polyketide synthesis in 96% ee.

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Article information

DOI
https://doi.org/10.1039/B107995F
Article type
Communication
Submitted
05 Sep 2001
Accepted
01 Nov 2001
First published
22 Nov 2001

Chem. Commun., 2001, 2560-2561

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Facile enantioselective synthesis of a key homoallylic alcohol building block for polyketide synthesis: TiF4–BINOL catalyzed allylsilylation with allyl trimethylsilane

J. W. Bode, D. R. Gauthier Jr. and E. M. Carreira, Chem. Commun., 2001, 2560 DOI: 10.1039/B107995F

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