Issue 23, 2001
From the journal:

Chemical Communications

Electrochemistry of chalcogen compounds: prediction of antioxidant activity

Gregory I. Giles,a   Karen M. Tasker,a   Russell J. K. Johnson,a   Claus Jacob,*a   Chris Peersb  and  Kim N. Greenb  

* Corresponding authors

a School of Chemistry, University of Exeter, Stocker Road, Exeter, UK
E-mail: C.Jacob@ex.ac.uk;
Fax: +44 (0)1392 263434;
Tel: +44 (0)1392 263462

b Institute for Cardiovascular Research, University of Leeds, Leeds, UK

Abstract

Synthesis and characterisation of organochalcogens has demonstrated a high correlation between their electrochemical oxidation potential on the glassy carbon electrode, their activity in bioassays and an unprecedented antioxidant activity in neuronal cell culture (EC50 ∼ 20 nM) making electrochemical methodology a valuable tool in drug design for Alzheimer’s and related diseases.

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Article information

DOI
https://doi.org/10.1039/B107972G
Article type
Communication
Submitted
04 Sep 2001
Accepted
19 Oct 2001
First published
15 Nov 2001

Chem. Commun., 2001, 2490-2491

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Electrochemistry of chalcogen compounds: prediction of antioxidant activity

G. I. Giles, K. M. Tasker, R. J. K. Johnson, C. Jacob, C. Peers and K. N. Green, Chem. Commun., 2001, 2490 DOI: 10.1039/B107972G

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