Issue 23, 2001
From the journal:

Chemical Communications

Linear dichroism for the detection of single base pair mutations†

David J. Halsall,a   Alison Rodger*b  and  Timothy R. Daffornc  

* Corresponding authors

a Department of Clinical Biochemistry, Addenbrooke’s Hospital, Hills Rd, Cambridge, UK

b Department of Chemistry, University of Warwick, Coventry, UK
E-mail: a.rodger@warwick.ac.uk;
Fax: (+44) 24 76524112

c Department of Haematology, Cambridge Institute of Medical Research, Wellcome Trust/MRC Building, Hills Rd, Cambridge, UK

Abstract

Flow linear dichroism is shown to be able to detect single base mismatches in a polymerase chain reaction (PCR) amplimers from exon 10 of the human β-glucocerebrosidase gene (associated with Gaucher disease) over a kilobase long with no post PCR manipulation.

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Article information

DOI
https://doi.org/10.1039/B107830P
Article type
Communication
Submitted
30 Aug 2001
Accepted
08 Oct 2001
First published
08 Nov 2001

Chem. Commun., 2001, 2410-2411

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Linear dichroism for the detection of single base pair mutations

D. J. Halsall, A. Rodger and T. R. Dafforn, Chem. Commun., 2001, 2410 DOI: 10.1039/B107830P

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