Issue 20, 2001
From the journal:

Chemical Communications

Universal hybridization using LNA (locked nucleic acid) containing a novel pyrene LNA nucleotide monomer

B. Ravindra Babua  and  Jesper Wengel*a  

* Corresponding authors

a Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
E-mail: jwe@chem.sdu.dk

Abstract

A novel pyrene LNA nucleotide monomer is shown to mediate universal hybridization when incorporated into a DNA strand or a 2′-OMe-RNA/LNA chimeric strand. For the latter, high-affinity universal hybridization without compromising the base-pairing selectivity of bases neighbouring the universal pyrene LNA nucleotide monomer is documented.

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Article information

DOI
https://doi.org/10.1039/B106065C
Article type
Communication
Submitted
09 Jul 2001
Accepted
21 Aug 2001
First published
02 Oct 2001

Chem. Commun., 2001, 2114-2115

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Universal hybridization using LNA (locked nucleic acid) containing a novel pyrene LNA nucleotide monomer

B. R. Babu and J. Wengel, Chem. Commun., 2001, 2114 DOI: 10.1039/B106065C

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