Issue 18, 2001
From the journal:

Chemical Communications

Vitamin C induced decomposition of lipid hydroperoxides: direct evidence of genotoxin–DNA binding detected by QCRS

Karl D. Pavey,*a   Mijan Miah,a   Flavia Fucassi,a   Frank Paulb  and  Peter J. Cragg*a  

* Corresponding authors

a School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewes Road, Brighton, UK
E-mail: K.D.Pavey@bton.ac.uk, P.J.Cragg@bton.ac.uk

b Technology Development, Discovery Research, GlaxoSmithKline Pharmaceuticals, NFSP (North), Third Avenue, Harlow, Essex, UK

Abstract

We report direct evidence for human DNA-binding to precursors of mutagenic lesion-inducing compounds, produced form the vitamin C induced decomposition of lipid hydroperoxides, using a quartz crystal resonant sensor assay.

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Article information

DOI
https://doi.org/10.1039/B105766A
Article type
Communication
Submitted
02 Jul 2001
Accepted
15 Aug 2001
First published
04 Sep 2001

Chem. Commun., 2001, 1886-1887

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Vitamin C induced decomposition of lipid hydroperoxides: direct evidence of genotoxin–DNA binding detected by QCRS

K. D. Pavey, M. Miah, F. Fucassi, F. Paul and P. J. Cragg, Chem. Commun., 2001, 1886 DOI: 10.1039/B105766A

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