Issue 19, 2001
From the journal:

Chemical Communications

3′-Amino-2′,4′-BNA: novel bridged nucleic acids having an N3′→P5′ phosphoramidate linkage

Satoshi Obika,a   Mayumi Onoda,a   Koji Morita,b   Jun-ichi Andoh,a   Makoto Koizumib  and  Takeshi Imanishi*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, Japan.
E-mail: imanishi@phs.osaka-u.ac.jp;
Fax: (+81) 6-6879-8204;
Tel: (+81) 6-6879-8200

b Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa, Tokyo, Japan.

Abstract

Novel oligonucleotide analogues, containing a 3′-amino-2′,4′-BNA unit, were successfully synthesized, and they showed superior duplex and triplex forming ability as well as BNA itself, along with remarkable enzymatic stability.

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Article information

DOI
https://doi.org/10.1039/B105640A
Article type
Communication
Submitted
27 Jun 2001
Accepted
24 Aug 2001
First published
18 Sep 2001

Chem. Commun., 2001, 1992-1993

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3′-Amino-2′,4′-BNA: novel bridged nucleic acids having an N3′→P5′ phosphoramidate linkage

S. Obika, M. Onoda, K. Morita, J. Andoh, M. Koizumi and T. Imanishi, Chem. Commun., 2001, 1992 DOI: 10.1039/B105640A

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