Issue 20, 2001

Extreme (109) acidification of adenine-NH2 in an open platinated nucleobase quartet. A pH switch with potential as a biological acid/base catalystElectronic supplementary information (ESI) available: table of the determined values of the different evaluated protons and Figures of the fits under discussion. See http://www.rsc.org/suppdata/cc/b1/b105395g/

Abstract

The combination of electronic effects (PtII binding to N7 and N1) and a favourable conformation permitting efficient stabilization of the anion brings about a 109 fold increase in the exocyclic amino group acidity of 9-ethyladenine.

Graphical abstract: Extreme (109) acidification of adenine-NH2 in an open platinated nucleobase quartet. A pH switch with potential as a biological acid/base catalyst

Supplementary files

Article information

Article type
Communication
Submitted
20 Jun 2001
Accepted
23 Aug 2001
First published
18 Sep 2001

Chem. Commun., 2001, 2058-2059

Extreme (109) acidification of adenine-NH2 in an open platinated nucleobase quartet. A pH switch with potential as a biological acid/base catalyst

M. S. Lüth, M. Willermann and B. Lippert, Chem. Commun., 2001, 2058 DOI: 10.1039/B105395G

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