Issue 16, 2001
From the journal:

Chemical Communications

Linear fluorescent oligonucleotide probes with an acridine quencher generate a signal upon hybridisation

Rohan T. Ranasinghe,a   Lynda J. Brownb  and  Tom Brown*a  

* Corresponding authors

a Department of Chemistry, University of Southampton, Highfield, Southampton, UK
E-mail: tb2@soton.ac.uk;
Fax: +44 (0)23 80592991;
Tel: +44 (0)23 80592974

b Oswel Research Products Ltd., Medical and Biological Sciences Building, University of Southampton, Bassett Crescent East, Southampton, UK
E-mail: oswel@compuserve.com;
Fax: +44 (0)23 80592982/3;
Tel: +44 (0)23 80592984/5

Abstract

Linear, single stranded probes incorporating a fluorophore and an acridine moiety are weakly fluorescent until hybridised to a complementary target nucleic acid whereupon fluorescence increases due to reduced quenching.

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Article information

DOI
https://doi.org/10.1039/B104421B
Article type
Communication
Submitted
18 May 2001
Accepted
26 Jun 2001
First published
23 Jul 2001

Chem. Commun., 2001, 1480-1481

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Linear fluorescent oligonucleotide probes with an acridine quencher generate a signal upon hybridisation

R. T. Ranasinghe, L. J. Brown and T. Brown, Chem. Commun., 2001, 1480 DOI: 10.1039/B104421B

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