Antibody-catalyzed activation of a model tripartate prodrug by a tandem hydrolysis–1,6-elimination reactionElectronic supplementary information (ESI) available: the synthesis and characterization of 3, and 9–11, and experimental details for kinetic studies and Lineweaver–Burk plots. See http://www.rsc.org/suppdata/cc/b1/b103971g/
Abstract
Activation of a model tripartate prodrug was achieved by abzyme-catalyzed hydrolysis of an N-methylcarbamate moiety followed by a spontaneous 1,6-elimination reaction.