Issue 16, 2001
From the journal:

Chemical Communications

Highly specific oxidative damage of double-strand DNA by copper aminoglycosidesElectronic supplementary information (ESI) available: experimental section and complete HPLC trace for the truncated version shown in Fig. 2B. See http://www.rsc.org/suppdata/cc/b1/b103789g/

Anjali Patwardhana  and  J. A. Cowan*a  

* Corresponding authors

a Evans Laboratory of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio, USA.
E-mail: cowan@chemistry.ohio-state.edu

Abstract

Oxidative cleavage of double-strand DNA, mediated by either Cu2+-neamine 1 or Cu2+-kanamycin A 2, is shown to follow a highly specific C-4′ H mediated pathway and suggests a mechanism for efficient double-strand scission of duplex DNA.

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Article information

DOI
https://doi.org/10.1039/B103789G
Article type
Communication
Submitted
26 Apr 2001
Accepted
22 Jun 2001
First published
23 Jul 2001

Chem. Commun., 2001, 1490-1491

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Highly specific oxidative damage of double-strand DNA by copper aminoglycosides

A. Patwardhan and J. A. Cowan, Chem. Commun., 2001, 1490 DOI: 10.1039/B103789G

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