Issue 14, 2001
From the journal:

Chemical Communications

Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin

Alan M. Sandercock,a   Elizabeth H. Charles,a   Wendy Scaife,a   Peter N. Kirkpatrick,a   Simon W. O’Brien,a   Eduardo A. Papageorgiou,a   Jonathan B. Spencer*a  and  Dudley H. Williams*a  

* Corresponding authors

a Cambridge Centre for Molecular Recognition, University Chemical Laboratories, Lensfield Road, Cambridge, UK
E-mail: dhw1@cam.ac.uk;
Fax: +44 1223 336913;
Tel: +44 1223 336368

Abstract

The biosynthetic pathway to the L-di-meta-hydroxyphenylglycine (DHPG) constituent of chloroeremomycin (A82846B), has been investigated by a combination of feeding experiments with 13C-labelled substrates, and expression and assay of HpgT from the chloroeremomycin biosynthetic cluster.

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Article information

DOI
https://doi.org/10.1039/B103668H
Article type
Communication
Submitted
24 Apr 2001
Accepted
29 May 2001
First published
20 Jun 2001

Chem. Commun., 2001, 1252-1253

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Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin

A. M. Sandercock, E. H. Charles, W. Scaife, P. N. Kirkpatrick, S. W. O’Brien, E. A. Papageorgiou, J. B. Spencer and D. H. Williams, Chem. Commun., 2001, 1252 DOI: 10.1039/B103668H

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