Issue 13, 2001
From the journal:

Chemical Communications

Extended scope of in situiodotrimethylsilane mediated selective reduction of benzylic alcohols

Gary A. Cain*a  and  Edward R. Hollera  

* Corresponding authors

a Chemical and Physical Sciences, DuPont Pharmaceuticals Company, P.O. Box 80336, Experimental Station E336/109, Wilmington, DE, USA
E-mail: gary.a.cain@dupontpharma.com

Abstract

Iodotrimethylsilane, generated in situ from chlorotrimethylsilane and sodium iodide in acetonitrile, selectively reduces moderately electron deficient benzylic alcohols to the analogous toluenes; other reduction sensitive functional groups such as ketone, aldehyde, nitrile, and nitro are unaffected.

Graphical abstract: Extended scope of in situ iodotrimethylsilane mediated selective reduction of benzylic alcohols

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Article information

DOI
https://doi.org/10.1039/B102495G
Article type
Communication
Submitted
14 Mar 2001
Accepted
07 May 2001
First published
25 May 2001

Chem. Commun., 2001, 1168-1169

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Extended scope of in situ iodotrimethylsilane mediated selective reduction of benzylic alcohols

G. A. Cain and E. R. Holler, Chem. Commun., 2001, 1168 DOI: 10.1039/B102495G

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