Issue 13, 2001
From the journal:

Chemical Communications

New insight on the photoreactivity of the phototoxic anti-cancer flutamide: photochemical pathways selectively locked and unlocked by structural changes upon drug compartmentalization in phospholipid bilayer vesicles

Salvatore Sortino,*a   Giancarlo Marconib  and  Giuseppe Condorellia  

* Corresponding authors

a Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 8, Catania, Italy.
E-mail: ssortino@mbox.unict.it

b Istituto di Fotochimica e Radiazioni d’Alta Energia, Area della Ricerca, Via Pietro Gobetti 101, Bologna, Italy

Abstract

It is shown that structural changes of the phototoxic anti-cancer drug flutamide after its compartmentalization in unilamellar phospholipid bilayer vesicles lead to a highly selective modification of the photochemical outcome, locking the main photodegradation pathways observed in homogeneous media and unlocking a new and more efficient photoreactive channel.

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Article information

DOI
https://doi.org/10.1039/B102359B
Article type
Communication
Submitted
13 Mar 2001
Accepted
29 May 2001
First published
14 Jun 2001

Chem. Commun., 2001, 1226-1227

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New insight on the photoreactivity of the phototoxic anti-cancer flutamide: photochemical pathways selectively locked and unlocked by structural changes upon drug compartmentalization in phospholipid bilayer vesicles

S. Sortino, G. Marconi and G. Condorelli, Chem. Commun., 2001, 1226 DOI: 10.1039/B102359B

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