The first application of SelectfluorTM in electrophilic fluorination of amines: a new route to –NF2, –NHF, and >NF compounds

Abstract

Reactions of primary amines, RNH₂ [R = (CH₃)₃C–, (CH₃)₂CH–, CH₃(CH₂)₂–, (CH₃)₂CHCH₂–, CH₃(CH₂)₃–] and secondary amines, R₂NH [(R = CH₃CH₂–, CH₃(CH₂)₂–, (CH₃)₂CHCH₂–], with Selectfluor™ in acetonitrile or DMF or DMA result in formation of the corresponding RNF₂, RNHF, and R₂NF in high yields.