Fundamental design aspects of amphiphilicshell-crosslinked nanoparticles for controlled release applications

K. Shanmugananda Murthy; Qinggao Ma; Christopher G. Clark Jr.; Edward E. Remsen; Karen L. Wooley

doi:10.1039/B100819F

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Fundamental design aspects of amphiphilic shell-crosslinked

K. Shanmugananda Murthy,^a Qinggao Ma,^a Christopher G. Clark Jr.,^a Edward E. Remsen^a and Karen L. Wooley*^a

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* Corresponding authors

^a Department of Chemistry, Washington University, One Brookings Drive, CB 1134, St. Louis, MO 63130, USA.
E-mail: klwooley@artsci.wustl.edu;
Fax: +1 (314) 935 9844;
Tel: +1 (314) 935 7136

Abstract

A unique method is developed for the controlled release of the hydrophobic polymer chains from the core of the shell crosslinked nanoparticles (SCKs) by selective cleavage of labile C–ON bonds present at the core–shell interface; this represents a methodology to probe the permeability of nanoscopic membranes and a means for applications in the controlled release of macromolecular species.

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Article information

DOI: https://doi.org/10.1039/B100819F
Article type: Communication
Submitted: 19 Jan 2001
Accepted: 15 Mar 2001
First published: 03 Apr 2001

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Chem. Commun., 2001, 773-774

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Fundamental design aspects of amphiphilic shell-crosslinked nanoparticles for controlled release applications

K. Shanmugananda Murthy, Q. Ma, C. G. Clark Jr., E. E. Remsen and K. L. Wooley, Chem. Commun., 2001, 773 DOI: 10.1039/B100819F

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