Backbone dynamics and amide proton exchange at the two sides of the eremomycin dimer by 15N NMRElectronic supplementary information (ESI) is available: eremomycin production and isolation of 15N eremomycin. See http://www.rsc.org/suppdata/cc/b0/b010144n/

Abstract

¹⁵ N-labelling of the glycopeptide antibiotic eremomycin has made possible the dynamic characterization of the two sides of the dimer; in the presence of acetate anion the backbone amides are dynamically equivalent and the fastest amide proton exchange rate was found at the heart of the binding pocket.