Issue 4, 2001
From the journal:

Chemical Communications

First anti-oestrogen in the cyclopentadienyl rhenium tricarbonyl series. Synthesis and study of antiproliferative effects

Gérard Jaouen,*a   Siden Top,a   Anne Vessières,a   Pascal Pigeon,a   Guy Leclercqb  and  Ionna Laiosb  

* Corresponding authors

a Laboratoire de Chimie Organométallique, Ecole Nationale Supérieure de Chimie de Paris, UMR 7576, 11 rue Pierre et Marie Curie, Paris Cedex 05, France.
E-mail: jaouen@ext.jussieu.fr

b Laboratoire de Cancérologie Mammaire, Institut Jules Bordet, Rue Héger Bordet, 1 Brussels, Belgium.
E-mail: lcanmamm@ulb.ac.be

Abstract

A route to the organometallic complex 8 is described, along with a study of its antiproliferative effects on breast cancer cell lines; in the examples studied, 8 behaves in a very similar manner to tamoxifen, suggesting new possibilities for applications in organometallic chemistry.

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Article information

DOI
https://doi.org/10.1039/B009553M
Article type
Communication
Submitted
28 Nov 2000
Accepted
18 Jan 2001
First published
08 Feb 2001

Chem. Commun., 2001, 383-384

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First anti-oestrogen in the cyclopentadienyl rhenium tricarbonyl series. Synthesis and study of antiproliferative effects

G. Jaouen, S. Top, A. Vessières, P. Pigeon, G. Leclercq and I. Laios, Chem. Commun., 2001, 383 DOI: 10.1039/B009553M

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