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Issue 3, 2001
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Liquid chromatography with post-column electrochemical treatmentand mass spectrometric detection of non-polar compounds

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Abstract

The first hyphenation of high performance liquid chromatography (HPLC), electrochemical online oxidation and mass spectrometry (MS) is described. Ferrocenecarboxylic acid esters of various alcohols and phenols have been synthesized, separated by reversed-phase HPLC and oxidized (ionized) coulometrically prior to single quadrupole MS analysis using electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) interfaces. The dependence of the ionization on the electrochemical pretreatment is demonstrated. Limits of detection for selected derivatives range from 4 × 10−9 to 4 × 10−7 mol dm−3 depending on the individual compound and the selected interface.

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Publication details

The article was received on 13 Nov 2000, accepted on 18 Jan 2001 and first published on 05 Feb 2001


Article type: Communication
DOI: 10.1039/B009064F
Citation: Analyst, 2001,126, 288-290
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    Liquid chromatography with post-column electrochemical treatment and mass spectrometric detection of non-polar compounds

    G. Diehl, A. Liesener and U. Karst, Analyst, 2001, 126, 288
    DOI: 10.1039/B009064F

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