Issue 11, 2000
From the journal:

Journal of the Chemical Society, Perkin Transactions 2

Microwave-enhanced hydrogen isotope exchange studies of heterocyclic compounds

Sumathy Anto,a   Gareth S. Getvoldsen,a   John R. Harding,b   John R. Jones,a   Shui-Yu Lua  and  Jeremy C. Russellc  

a Department of Chemistry, School of Physics and Chemistry, University of Surrey, Guildford, Surrey, UK
E-mail: j.r.jones@surrey.ac.uk

b AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK

c Biocompatibles Ltd, Frensham House, Frensham Business Park, Weydon Lane, Farnham, Surrey, UK

Abstract

The microwave-enhanced hydrogen–deuterium exchange reaction of a number of nitrogen-containing heterocyclic compounds has been achieved extremely rapidly (<20 min) via their hydrochloride salts, whilst the corresponding Raney-nickel catalysed reactions of indole and N-methylindole are also complete in a similar time interval. Furthermore, the pattern of labelling in the latter reaction depends critically on the choice of solvent used.

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Article information

DOI
https://doi.org/10.1039/B005724J
Article type
Paper
Submitted
17 Jul 2000
Accepted
18 Sep 2000
First published
18 Oct 2000

J. Chem. Soc., Perkin Trans. 2, 2000, 2208-2211

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Microwave-enhanced hydrogen isotope exchange studies of heterocyclic compounds

S. Anto, G. S. Getvoldsen, J. R. Harding, J. R. Jones, S. Lu and J. C. Russell, J. Chem. Soc., Perkin Trans. 2, 2000, 2208 DOI: 10.1039/B005724J

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