Issue 19, 2000
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

A novel stereo-controlled nucleobase exchange process for the synthesis of 2′-C-branched nucleosides

Volker Fehring,a   Mai Yee Chan,a   Ian A. O’Neil*a  and  Richard Cosstick*a  

* Corresponding authors

a Department of Chemistry, University of Liverpool, Crown St, Liverpool, UK
E-mail: rcosstic@liverpool.ac.uk

Abstract

A novel stereo-controlled process is described which enables the uracil base on a 2′-deoxy-2′-α-C-carboxymethyluridine nucleoside to be exchanged for either a purine or another pyrimidine base, via the intermediacy of an isolable pentofuranosyl butyrolactone.

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Article information

DOI
https://doi.org/10.1039/B007099H
Article type
Communication
Submitted
02 Jun 2000
Accepted
31 Aug 2000
First published
15 Sep 2000

J. Chem. Soc., Perkin Trans. 1, 2000, 3185-3187

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A novel stereo-controlled nucleobase exchange process for the synthesis of 2′-C-branched nucleosides

V. Fehring, M. Y. Chan, I. A. O’Neil and R. Cosstick, J. Chem. Soc., Perkin Trans. 1, 2000, 3185 DOI: 10.1039/B007099H

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