Synthesis and reactions of Biginelli-compounds. Part 23.1 Chemoenzymatic syntheses of enantiomerically pure 4-aryl-3,4-dihydropyrimidin-2(1H
)-ones
Abstract
Enantiomerically pure dihydropyrimidones (DHPMs) were prepared by lipase-catalyzed enzymatic resolution of two types of activated DHPM )-13 on a semi-preparative scale. Treatment of (R)-13 with