Issue 19, 2000
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Asymmetric reduction of ketones by Geotrichum candidum in the presence of AmberliteTM XAD, a solid organic solvent

Kaoru Nakamura,*a   Mikio Fujiib  and  Yoshiteru Idab  

* Corresponding authors

a Institute for Chemical Research, Kyoto University, Kyoto, Uji, Japan

b School of Pharmaceutical Science, Showa University, 1-5-8 Hatanodai, Tokyo, Shinagawa-ku, Japan

Abstract

A hydrophobic polymer, Amberlite™ XAD, was used as material to control the stereochemical course of microbial reductions. In the presence of XAD, simple aliphatic and aromatic ketones were reduced to the corresponding (S )-alcohols in excellent enantiomeric excess (ee) while low enantioselectivities were observed in the absence of the polymer.

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Article information

DOI
https://doi.org/10.1039/B005204N
Article type
Paper
Submitted
29 Jun 2000
Accepted
14 Aug 2000
First published
18 Sep 2000

J. Chem. Soc., Perkin Trans. 1, 2000, 3205-3211

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Asymmetric reduction of ketones by Geotrichum candidum in the presence of AmberliteTM XAD, a solid organic solvent

K. Nakamura, M. Fujii and Y. Ida, J. Chem. Soc., Perkin Trans. 1, 2000, 3205 DOI: 10.1039/B005204N

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