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Issue 20, 2000
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Syntheses of isotopically labelled L-α-amino acids with an asymmetric centre at C-3

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Abstract

Approaches are described to the synthesis of a series of isotopically labelled L-α-amino acids each with an asymmetric centre at C-3, including isoleucine, allo-isoleucine, threonine and allo-threonine. The methods may be simply adapted for the selective incorporation of an isotopic label at each site of L-valine including the selective labelling of either diastereotopic methyl group with carbon-13 and/or deuterium and labelling of the amine with nitrogen-15.

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Article information


Submitted
28 Jun 2000
Accepted
14 Aug 2000
First published
28 Sep 2000

J. Chem. Soc., Perkin Trans. 1, 2000, 3406-3416
Article type
Paper

Syntheses of isotopically labelled L-α-amino acids with an asymmetric centre at C-3

J. R. Harding, R. A. Hughes, N. M. Kelly, A. Sutherland and C. L. Willis, J. Chem. Soc., Perkin Trans. 1, 2000, 3406
DOI: 10.1039/B005172L

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