Issue 19, 2000

The synthesis and reactivity of optically pure amino acids bearing side-chain thioamides

Abstract

The synthesis and reactivity of fully protected thioamide analogues of asparagine and glutamine are described. A key feature of the synthetic strategies employed was the ability to perform selective thiations on multiple carbonyl-containing substrates. Also described are the preparations of thioamide derivatives of phenylalanine. The utility of these amino acid derivatives for solid-phase peptide synthesis is discussed.

Article information

Article type
Paper
Submitted
13 Jun 2000
Accepted
04 Jul 2000
First published
14 Sep 2000

J. Chem. Soc., Perkin Trans. 1, 2000, 3227-3231

The synthesis and reactivity of optically pure amino acids bearing side-chain thioamides

J. M. Sanderson, P. Singh, C. W. G. Fishwick and J. B. C. Findlay, J. Chem. Soc., Perkin Trans. 1, 2000, 3227 DOI: 10.1039/B004688O

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