Issue 19, 2000
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthesis of β-substituted alanines viaMichael addition of nucleophiles to dehydroalanine derivatives

Paula M. T. Ferreira,a   Hernâni L. S. Maia,*a   Luís S. Monteiro,a   Joana Sacramentoa  and  Joana Sebastiãoa  

* Corresponding authors

a Department of Chemistry, University of Minho, Gualtar, Braga, Portugal

Abstract

Several β-substituted alanines are synthesised in high yields by a Michael addition of nucleophiles to N-acyl-N-(tert-butoxycarbonyl)dehydroalanine methyl ester, using mild reaction conditions and simple work-up procedures. The same method can be applied to dipeptides containing dehydroalanine.

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Article information

DOI
https://doi.org/10.1039/B003353G
Article type
Paper
Submitted
26 Apr 2000
Accepted
10 Jul 2000
First published
13 Sep 2000

J. Chem. Soc., Perkin Trans. 1, 2000, 3317-3324

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Synthesis of β-substituted alanines via Michael addition of nucleophiles to dehydroalanine derivatives

P. M. T. Ferreira, H. L. S. Maia, L. S. Monteiro, J. Sacramento and J. Sebastião, J. Chem. Soc., Perkin Trans. 1, 2000, 3317 DOI: 10.1039/B003353G

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