1,7-Asymmetric induction of chirality in a Mukaiyama aldol reaction using π-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of α-substituted β-hydroxy carbonyl compounds
Abstract
Silyl enol ethers derived from ethyl ketone functionalised π-allyltricarbonyliron lactone complexes undergo highly diastereoselective Mukaiyama aldol reactions with a variety of achiral aldehydes, with control of both α- and β-stereogenic centres.