Issue 16, 2000
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthesis of model compounds for potential contrast agents containing phosphonate and peptide moieties

Hutti Shalem,a   Shimon Shatzmiller*b  and  Ben-Ami Feita  

* Corresponding authors

a The Raymond and Beverly Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel

b The College of Jeudea and Samaria, Israel

Abstract

The synthesis of dimethyl 2-acetoxy-2-(2,4-diiodo-5-aminophenyl)ethylphosphonate and dimethyl 2-acetoxy-2-(2,4,6-triiodo-3,5-diaminophenyl)ethylphosphonate is described. Several amido and peptidic derivatives of these two compounds were prepared. These products are composed of a combination of structural/functional moieties which pave the way for their potential application as non-ionic selective X-ray contrast agents.

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Article information

DOI
https://doi.org/10.1039/A909086J
Article type
Paper
Submitted
16 Nov 1999
Accepted
19 Apr 2000
First published
07 Jul 2000

J. Chem. Soc., Perkin Trans. 1, 2000, 2831-2837

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Synthesis of model compounds for potential contrast agents containing phosphonate and peptide moieties

H. Shalem, S. Shatzmiller and B. Feit, J. Chem. Soc., Perkin Trans. 1, 2000, 2831 DOI: 10.1039/A909086J

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