The first isolation and crystal structure of a boron difluoro complex (isoflavone yellow). Biologically active intermediates produced during isoflavone synthesis

Abstract

The yellow intermediate 4f produced during the reaction of the deoxybenzoin 3f with N,N′-dimethyl(chloromethylene)ammonium chloride in the presence of BF₃·Et₂O prior to the formation of the corresponding isoflavone was isolated for the first time and characterized by NMR, MS and single-crystal X-ray diffraction techniques. These yellow intermediates showed anticancer, nematicidal and mosquitocidal activities.