Issue 2, 2000

Unexpected isomerization in the series of fluorine-containing 2,3-dihydro-1H-1,4-diazepines with a 2-aminoethyl group at one of the nitrogen atoms

Abstract

Under kinetic control conditions, 6-methoxy-2-(1,1,2,2-tetrafluoroethyl)chromone reacts with diethylenetriamine to form 5-(2-hy-droxy-5-methoxyphenyl)-7-(1,1,2,2-tetrafluoroethyl)-1,4,8-triazabicyclo[5.3.0]dec-4-ene, and the latter undergoes isomerization to the title compound, which is more thermodynamically stable.

Article information

Article type
Paper

Mendeleev Commun., 2000,10, 56-58

Unexpected isomerization in the series of fluorine-containing 2,3-dihydro-1H-1,4-diazepines with a 2-aminoethyl group at one of the nitrogen atoms

V. Y. Sosnovskikh, I. I. Vorontsov, V. A. Kutsenko and Y. G. Yatluk, Mendeleev Commun., 2000, 10, 56 DOI: 10.1070/MC2000v010n02ABEH001209

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