On oxyhalogenation, acids, and non-mimics of bromoperoxidase enzymes

Abstract

In contrast to recent studies, molybdenum(VI) and vanadium(V) catalysed oxidative bromination reactions are found to depend on the presence of stoichiometric amounts of acid. Thus, recent reports on Lewis-acid catalysed oxybromination systems are re-examined. The relevance of these systems as bromoperoxidase enzyme mimics and also the potential application of enzymatic halogenation as a ‘green’ bromination option are discussed.