One electron at a time oxidations and enzymatic paradigms: from metallic to non-metallic redox centers

Abstract

Biomimetic models of redox metalloenzymes may serve to elucidate structure and mechanisms of these enzymes and, moreover, new catalysts for synthesis can ensue from these models. A number of metalloenzymes utilize free radicals as a catalytic competent cofactor to promote oxidation reactions. Non metallic redox centers (free radicals) may be an advantageous alternative to metallic centers. Several biomimetic approaches are described concerning two selected enzymes, copper–zinc superoxide dismutase and galactose oxidase. The advantages of organic radical instead of metallic centers in abstracting hydrogen atoms are discussed.

Paradigme: il s’agit, à partir d’un objet assez simple de découvrir une structure qui se retrouvera dans un objet plus élevé.

Dictionnaire de Philosophie (Nathan ed. 1990)