Issue 12, 2000

Specific complexation of ursodeoxycholic acid with guest compounds induced by co-grinding

Abstract

Ursodeoxycholic acid (UDCA) was ground with a variety of organic compounds using a vibrational mill. Only when either phenanthrene or anthrone was used did powder X-ray diffraction and thermal analysis data indicate that a specific interaction developed with UDCA in the ground mixture. From fluorescence and infrared spectroscopic data, inclusion complex formation with UDCA was suggested during the co-grinding process. The stoichiometry of the inclusion compounds of UDCA–phenanthrene/anthrone was evaluated as a 1:1 molar ratio. Interestingly, no complexes could be obtained by the coprecipitation method, which was conventionally applied for the preparation of inclusion complex of bile acids. Consequently, except when the co-grinding process was performed with either phenanthrene or anthrone, UDCA did not form an inclusion complex.

Article information

Article type
Paper
Submitted
29 Feb 2000
Accepted
17 Apr 2000
First published
24 May 2000

Phys. Chem. Chem. Phys., 2000,2, 2815-2820

Specific complexation of ursodeoxycholic acid with guest compounds induced by co-grinding

T. Oguchi, K. Kazama, E. Yonemochi, S. Churimaworapan, W. Choi, S. Limmatvapirat and K. Yamamoto, Phys. Chem. Chem. Phys., 2000, 2, 2815 DOI: 10.1039/B001644F

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