Unusual RNA and DNA binding properties of a novel pyrrolidine–amide oligonucleotide mimic (POM)Electronic supplementary information (ESI) available: UV thermal denaturation curves, Job plots and SPR sensograms for TS-POM 3 binding to DNA and RNA. See http://www.rsc.org/suppdata/cc/b0/b006903p/

Abstract

A pentameric thymidyl pyrrolidine–amide oligonucleotide mimic (POM) was synthesised and shown to bind with very high affinity to complementary single stranded RNA and DNA, whilst exhibiting kinetic binding selectivity for RNA over DNA.