Harnessing thorium(iv) as a catalyst: RNA and phosphate diester cleavage by a thorium(iv) macrocyclic complexElectronic supplementary information (ESI) available: 1H NMR spectra for [Th(1)](NO3)4 in D2O at 21 and 4 °C. See http://www.rsc.org/suppdata/cc/b0/b005866l

Abstract

A robust macrocyclic tetraamide complex of Th(IV) binds phosphate diesters and promotes cleavage of RNA and phosphate diesters at 37 °C in the pH range 5.00–7.90.