Issue 18, 2000

Best design of heterogenized β-aminoalcohols for improvement of enantioselective addition of diethylzinc to benzaldehyde

Abstract

Covalent immobilization of (1R,2S)-(−)-ephedrine, used as a model molecule of β-aminoalcohols, on the surface of MCM-41-type mesoporous aluminosilicates, performed by a new sol–gel method, leads to chiral auxiliaries which show greatly enhanced rates and ee’s compared to those reported up to now in the enantioselective addition of diethylzinc to benzaldehyde.

Article information

Article type
Communication
Submitted
10 Jul 2000
Accepted
04 Aug 2000
First published
04 Sep 2000

Chem. Commun., 2000, 1773-1774

Best design of heterogenized β-aminoalcohols for improvement of enantioselective addition of diethylzinc to benzaldehyde

S. Abramson, M. Laspéras, A. Galarneau, D. Desplantier-Giscard and D. Brunel, Chem. Commun., 2000, 1773 DOI: 10.1039/B005518M

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