Remarkable enhancement of the hydrolyses of phosphoesters by dinuclear centers: Streptomyces aminopeptidase as a ‘natural model system’Electronic supplementary information (ESI) available: Michaelis–Menten kinetics plots. See http://www.rsc.org/suppdata/cc/b0/b004544f/

Abstract

The transition-state analogues bis(p-nitrophenyl)phosphate and p-nitrophenyl phenylphosphonate for peptide hydrolysis are shown to be very effectively hydrolyzed by Streptomyces dinuclear aminopeptidase and its Co²⁺, Ni²⁺, Mn²⁺ and Cd²⁺ derivatives with high catalytic proficiencies and specific activities comparable to those of some phosphoesterases.