Degradation of an antitumour bicyclic hexapeptide   RA-VII into cycloisodityrosines

Yukio Hitotsuyanagi; Tomoyo Hasuda; Yuji Matsumoto; Kentaro Yamaguchi; Hideji Itokawa; Koichi Takeya

doi:10.1039/B004459H

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Degradation of an antitumour bicyclic hexapeptide RA-VII into cycloisodityrosines

Yukio Hitotsuyanagi,^a Tomoyo Hasuda,^a Yuji Matsumoto,^a Kentaro Yamaguchi,^b Hideji Itokawa^a and Koichi Takeya*^a

Author affiliations

* Corresponding authors

^a Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo, Japan.
E-mail: takeyak@ps.toyaku.ac.jp

^b Chemical Analysis Center, Chiba University, Yayoi-cho, Inage-ku, Chiba, Japan

Abstract

Degradation of an antitumour bicyclic hexapeptide, RA-VII 1, produced protected cycloisodityrosines in an efficient manner through bis(thioamide) intermediate 6.

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Supplementary files

Crystal structure data TXT (27K)

Article information

DOI: https://doi.org/10.1039/B004459H
Article type: Communication
Submitted: 05 Jun 2000
Accepted: 17 Jul 2000
First published: 09 Aug 2000

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Chem. Commun., 2000, 1633-1634

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Degradation of an antitumour bicyclic hexapeptide

RA-VII into cycloisodityrosines

Y. Hitotsuyanagi, T. Hasuda, Y. Matsumoto, K. Yamaguchi, H. Itokawa and K. Takeya, Chem. Commun., 2000, 1633 DOI: 10.1039/B004459H

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