Solid-phase synthesis of novel achiral hydantoin- and isoxazoline-substituted dispirocyclobutanoidsWe thank the National Science Foundation for financial support of this research and the National Science Foundation CRIF program (CHE-9808183) for Varian Inova 400 MHz and Mercury 300 MHz NMR instrument purchases.

Abstract

A synthesis of novel achiral hydantoin- and isoxazoline-substituted dispirocyclobutanoids from solid-phase synthesis has been achieved. The facial and selective Boc-NH-mediated hydrogen-bond delivery of the nitrile oxide afforded 6 as the major compound.