Issue 13, 2000
From the journal:

Chemical Communications

α-LNA, locked nucleic acid with α-d-configuration

Poul Nielsen*a  and  Jakob Kragh Dalskova  

* Corresponding authors

a Department of Chemistry, University of Southern Denmark, Odense University, Odense M, Denmark.
E-mail: pon@chem.sdu.dk

Abstract

The bicyclic thymine monomer of α-LNA (αTL) was efficiently synthesised and used in the synthesis of α-LNA sequences: incorporation of single αTL-monomers in α-configured oligothymidylates destabilises the affinity towards both complementary DNA and RNA, whereas a fully modified α-LNA sequence displays a very efficient recognition of complementary RNA.

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Article information

DOI
https://doi.org/10.1039/B003104F
Article type
Communication
Submitted
18 Apr 2000
Accepted
16 May 2000
First published
14 Jun 2000

Chem. Commun., 2000, 1179-1180

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α-LNA, locked nucleic acid with α-D-configuration

P. Nielsen and J. K. Dalskov, Chem. Commun., 2000, 1179 DOI: 10.1039/B003104F

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