Issue 5, 2000
From the journal:

Chemical Communications

Hydrolysis of an N-methylcarbamate by a catalytic antibodyThe synthesis and characterization of 4, 5, 6 and 7, preparation of monoclonal antibodies and ST51 Fab, experimental details for kinetic studies and Lineweaver–Burk plots are provided as electronic supplementary information, see http://www.rsc.org/suppdata/cc/b0/b000468p/

A. Nicole Dinaut,a   Mei-Jin Chen,a   Alex Marks,b   Robert A. Bateyc  and  Scott D. Taylor‡*a  

* Corresponding authors

a Department of Chemistry, University of Toronto, 3359 Mississauga Rd. North, Mississauga, Ontario, Canada

b Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Toronto, Ontario, Canada

c Department of Chemistry, University of Toronto, St. George Campus, 80 St. George Street, Toronto, Ontario, Canada

Abstract

The first example of antibody-catalyzed hydrolysis of an N-methylcarbamate, a highly challenging reaction for antibody catalysis, was achieved by raising a monoclonal antibody to a phosphoramidate transition state analogue.

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Article information

DOI
https://doi.org/10.1039/B000468P
Article type
Communication
Submitted
23 Dec 1999
Accepted
21 Jan 2000
First published
24 Feb 2000

Chem. Commun., 2000, 385-386

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Hydrolysis of an N-methylcarbamate by a catalytic antibody

A. N. Dinaut, M. Chen, A. Marks, R. A. Batey and S. D. Taylor, Chem. Commun., 2000, 385 DOI: 10.1039/B000468P

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