A very short reaction sequence opens with metal-mediated addition of commercial bromodifluoropropene to aldehydes; allylation under phase transfer catalysed conditions sets the stage for a ring closing metathesis (RCM) in the presence of commercial Grubbs’ catalyst to afford potentially useful difluorinated dihydropyrans.
Rapid syntheses of difluorinated dihydropyrans
J. M. Percy and S. Pintat, Chem. Commun., 2000, 607 DOI: 10.1039/B000006J
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