Unusual reaction of azetidine-2,3-diones with primaryamines. Straightforward asymmetric synthesis of α-amino acid andpeptide derivatives

Benito Alcaide; Pedro Almendros; Cristina Aragoncillo

doi:10.1039/A909688D

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Unusual reaction of azetidine-2,3-diones with primary amines. Straightforward asymmetric synthesis of α-amino acid and peptide derivatives

Benito Alcaide,*^a Pedro Almendros^a and Cristina Aragoncillo^a

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* Corresponding authors

^a Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain.
E-mail: alcaideb@eucmax.sim.ucm.es

Abstract

An unprecedented one-step synthesis of unnatural α-amino acid and peptide derivatives, in both the racemic and optically pure forms, using azetidine-2,3-diones as building blocks has been developed by treatment with primary amines.

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DOI: https://doi.org/10.1039/A909688D
Article type: Communication
Submitted: 09 Dec 1999
Accepted: 27 Mar 2000
First published: 13 Apr 2000

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Chem. Commun., 2000, 757-758

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Unusual reaction of azetidine-2,3-diones with primary amines. Straightforward asymmetric synthesis of α-amino acid and peptide derivatives

B. Alcaide, P. Almendros and C. Aragoncillo, Chem. Commun., 2000, 757 DOI: 10.1039/A909688D

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Chemical Communications

Unusual reaction of azetidine-2,3-diones with primary amines. Straightforward asymmetric synthesis of α-amino acid and peptide derivatives

Abstract

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Unusual reaction of azetidine-2,3-diones with primary amines. Straightforward asymmetric synthesis of α-amino acid and peptide derivatives

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